Is Barium Enema Reliable for the Diagnosis of Total Colonic Aganglionosis?

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Total Colonic Aganglionosis: Reappraisal of Contrast Enema Study

Total colonic aganglionosis (TCA) is a rare form of Hirschsprung disease (HD). It is difficult to be diagnosed on contrast enema because the radiographic findings are variable. The study aims to re-evaluate the contrast enema findings of TCA. From 2001 to 2009, 14 patients (11 males, 3 females; ages from 1 day to 6 months) with pathologically proven TCA were reviewed for demographic features, c...

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A Retrospective Cohort Study of Total Colonic Aganglionosis: Is the Appendix a Reliable Diagnostic Tool?

BACKGROUND Hirschsprung's disease (HD) is characterized by a lack of ganglion cells in the myenteric and submucosal plexus, associated with increased numbers of acetyl cholinesterase (AChE) positive nerve fibres. In approximately 10% of patients with HD the entire colon will be affected; a condition known as Total Colonic Aganglionosis (TCA). Aganglionosis of the appendix has long been consider...

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A Retrospective Cohort Study of Total Colonic Aganglionosis: Is the Appendix a Reliable Diagnostic Tool?

We would like the authors to note the recent review on the subject in Lane et al. “The Appendix and Aganglionosis. A Note of Caution-How the Histology Can Mislead the Surgeon in Total Colonic Hirschsprung’s Disease”, [2] This report showed that the appendix is not reliable in determining whether there is Hirschsprung’s disease as many normal appendices have no ganglion cells. When we looked at ...

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The Value of Urgent Barium Enema and Computed Tomography in Acute Malignant Colonic Obstruction: Is Urgent Barium Enema Still Necessary?

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Total Colonic Aganglionosis in Siblings

Hirschsprung’s disease (HD) is attributed to failure of craniocaudal neural crest cell migration in the hindgut. Histopathology is absent of ganglion cells in the myenteric and submucosal plexuses. Most patients present with intestinal obstruction, in which delayed meconium passage is the most important history when suspecting HD. In eighty percent of cases, the pathology is limited limited to ...

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ژورنال

عنوان ژورنال: Journal of the Korean Association of Pediatric Surgeons

سال: 2018

ISSN: 2383-5036,2383-5508

DOI: 10.13029/jkaps.2018.24.1.10